mpm 200 multiphoton microscope body Search Results


mpm 200 multiphoton microscope body  (Thorlabs)
86
Thorlabs mpm 200 multiphoton microscope body
Mpm 200 Multiphoton Microscope Body, supplied by Thorlabs, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mpm+200+multiphoton+microscope+body/pmc07559300-203-38-43?v=Thorlabs
Average 86 stars, based on 1 article reviews
mpm 200 multiphoton microscope body - by Bioz Stars, 2026-08
86/100 stars
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diaphot 200 microscope  (Nikon)
96
Nikon diaphot 200 microscope
Diaphot 200 Microscope, supplied by Nikon, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mpm+200+multiphoton+microscope+body/pmc02743958-157-16-15?v=Nikon
Average 96 stars, based on 1 article reviews
diaphot 200 microscope - by Bioz Stars, 2026-08
96/100 stars
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multiphoton laser scanning microscopy  (Olympus)
96
Olympus multiphoton laser scanning microscopy
Mechanistic evaluation of (SO 3 - )-MSN-PEG/TA on metastasis, focal adhesion turnover, angiogenesis, and tumor targeting. HCT-116 cells were treated with 200 μg/mL of (SO 3 - )-MSN-PEG/TA for 24 hours. (a) Western blot analysis of p-FAK expression levels. (b) Quantitative analysis of p-FAK protein expression relative to the control group (***p < 0.001, n = 3). (c) Immunofluorescence imaging of paxillin (green) and nuclei (blue). Scale bar: 20 μm. (d) Quantitative comparison of the number of FA per cell between control and treated groups (***p < 0.001, n = 5). (e) Schematic representation of the chicken embryo CAM assay. HCT-116 cells were seeded onto the CAM, and (SO 3 - )-MSN-PEG/TA (1 mg/egg) was administered intravenously on embryonic day 13. (f) Representative photographs of CAM vasculature on day 15. (g) Statistical analysis of vascular density performed using ImageJ software (***p < 0.001, n =5). (h) Schematic illustration of the in vivo tumor-targeting study. HCT-116 tumor-bearing mice were intravenously injected with RITC-labeled (SO3⁻)-MSN-PEG/TA (200 mg/kg) and analyzed by <t>multiphoton</t> <t>microscopy.</t> (i) Visualization of the EPR effect. Blood vessels were labeled with FITC–dextran (green), and RITC-labeled (SO3⁻)-MSN-PEG/TA (red) signals were observed 24 hours post-injection. Scale bar = 100 μm. (j) Schematic of the orthotopic colorectal cancer metastasis model. Luciferase-expressing HCT-116 tumor tissue (2 x 10⁶ cells) was implanted into the cecum wall of NOD-SCID mice to establish an orthotopic colorectal cancer model. Mice were intravenously treated with (SO 3 - )-MSN-PEG/TA (equivalent to NPs dose corresponding to 40 mg/kg of IRI@(SO 3 - )-MSN-PEG/TA). (k) Monitoring of orthotopic tumor growth by IVIS imaging from day 3 to day 31. (l) Ex vivo imaging of metastatic lesions: Post-mortem imaging of mice revealed extensive metastasis, with tumor sites identified in organs such as the liver, spleen, kidneys, stomach, and cecum (indicated by cyan arrows).
Multiphoton Laser Scanning Microscopy, supplied by Olympus, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mpm+200+multiphoton+microscope+body/bio_rxiv__2025__11__25__690433-149-44-49?v=Olympus
Average 96 stars, based on 1 article reviews
multiphoton laser scanning microscopy - by Bioz Stars, 2026-08
96/100 stars
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chameleon  (Coherent Corp)
96
Coherent Corp chameleon
Mechanistic evaluation of (SO 3 - )-MSN-PEG/TA on metastasis, focal adhesion turnover, angiogenesis, and tumor targeting. HCT-116 cells were treated with 200 μg/mL of (SO 3 - )-MSN-PEG/TA for 24 hours. (a) Western blot analysis of p-FAK expression levels. (b) Quantitative analysis of p-FAK protein expression relative to the control group (***p < 0.001, n = 3). (c) Immunofluorescence imaging of paxillin (green) and nuclei (blue). Scale bar: 20 μm. (d) Quantitative comparison of the number of FA per cell between control and treated groups (***p < 0.001, n = 5). (e) Schematic representation of the chicken embryo CAM assay. HCT-116 cells were seeded onto the CAM, and (SO 3 - )-MSN-PEG/TA (1 mg/egg) was administered intravenously on embryonic day 13. (f) Representative photographs of CAM vasculature on day 15. (g) Statistical analysis of vascular density performed using ImageJ software (***p < 0.001, n =5). (h) Schematic illustration of the in vivo tumor-targeting study. HCT-116 tumor-bearing mice were intravenously injected with RITC-labeled (SO3⁻)-MSN-PEG/TA (200 mg/kg) and analyzed by <t>multiphoton</t> <t>microscopy.</t> (i) Visualization of the EPR effect. Blood vessels were labeled with FITC–dextran (green), and RITC-labeled (SO3⁻)-MSN-PEG/TA (red) signals were observed 24 hours post-injection. Scale bar = 100 μm. (j) Schematic of the orthotopic colorectal cancer metastasis model. Luciferase-expressing HCT-116 tumor tissue (2 x 10⁶ cells) was implanted into the cecum wall of NOD-SCID mice to establish an orthotopic colorectal cancer model. Mice were intravenously treated with (SO 3 - )-MSN-PEG/TA (equivalent to NPs dose corresponding to 40 mg/kg of IRI@(SO 3 - )-MSN-PEG/TA). (k) Monitoring of orthotopic tumor growth by IVIS imaging from day 3 to day 31. (l) Ex vivo imaging of metastatic lesions: Post-mortem imaging of mice revealed extensive metastasis, with tumor sites identified in organs such as the liver, spleen, kidneys, stomach, and cecum (indicated by cyan arrows).
Chameleon, supplied by Coherent Corp, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mpm+200+multiphoton+microscope+body/custom%40chameleon%4030932006?v=Coherent+Corp
Average 96 stars, based on 1 article reviews
chameleon - by Bioz Stars, 2026-08
96/100 stars
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multiphoton tomograph mptflex  (JenLab GmbH)
90
JenLab GmbH multiphoton tomograph mptflex
Mechanistic evaluation of (SO 3 - )-MSN-PEG/TA on metastasis, focal adhesion turnover, angiogenesis, and tumor targeting. HCT-116 cells were treated with 200 μg/mL of (SO 3 - )-MSN-PEG/TA for 24 hours. (a) Western blot analysis of p-FAK expression levels. (b) Quantitative analysis of p-FAK protein expression relative to the control group (***p < 0.001, n = 3). (c) Immunofluorescence imaging of paxillin (green) and nuclei (blue). Scale bar: 20 μm. (d) Quantitative comparison of the number of FA per cell between control and treated groups (***p < 0.001, n = 5). (e) Schematic representation of the chicken embryo CAM assay. HCT-116 cells were seeded onto the CAM, and (SO 3 - )-MSN-PEG/TA (1 mg/egg) was administered intravenously on embryonic day 13. (f) Representative photographs of CAM vasculature on day 15. (g) Statistical analysis of vascular density performed using ImageJ software (***p < 0.001, n =5). (h) Schematic illustration of the in vivo tumor-targeting study. HCT-116 tumor-bearing mice were intravenously injected with RITC-labeled (SO3⁻)-MSN-PEG/TA (200 mg/kg) and analyzed by <t>multiphoton</t> <t>microscopy.</t> (i) Visualization of the EPR effect. Blood vessels were labeled with FITC–dextran (green), and RITC-labeled (SO3⁻)-MSN-PEG/TA (red) signals were observed 24 hours post-injection. Scale bar = 100 μm. (j) Schematic of the orthotopic colorectal cancer metastasis model. Luciferase-expressing HCT-116 tumor tissue (2 x 10⁶ cells) was implanted into the cecum wall of NOD-SCID mice to establish an orthotopic colorectal cancer model. Mice were intravenously treated with (SO 3 - )-MSN-PEG/TA (equivalent to NPs dose corresponding to 40 mg/kg of IRI@(SO 3 - )-MSN-PEG/TA). (k) Monitoring of orthotopic tumor growth by IVIS imaging from day 3 to day 31. (l) Ex vivo imaging of metastatic lesions: Post-mortem imaging of mice revealed extensive metastasis, with tumor sites identified in organs such as the liver, spleen, kidneys, stomach, and cecum (indicated by cyan arrows).
Multiphoton Tomograph Mptflex, supplied by JenLab GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mpm+200+multiphoton+microscope+body/pmc07662237-308-9-12?v=JenLab+GmbH
Average 90 stars, based on 1 article reviews
multiphoton tomograph mptflex - by Bioz Stars, 2026-08
90/100 stars
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a1r mp multiphoton advanced resolution confocal microscope  (Nikon)
96
Nikon a1r mp multiphoton advanced resolution confocal microscope
Mechanistic evaluation of (SO 3 - )-MSN-PEG/TA on metastasis, focal adhesion turnover, angiogenesis, and tumor targeting. HCT-116 cells were treated with 200 μg/mL of (SO 3 - )-MSN-PEG/TA for 24 hours. (a) Western blot analysis of p-FAK expression levels. (b) Quantitative analysis of p-FAK protein expression relative to the control group (***p < 0.001, n = 3). (c) Immunofluorescence imaging of paxillin (green) and nuclei (blue). Scale bar: 20 μm. (d) Quantitative comparison of the number of FA per cell between control and treated groups (***p < 0.001, n = 5). (e) Schematic representation of the chicken embryo CAM assay. HCT-116 cells were seeded onto the CAM, and (SO 3 - )-MSN-PEG/TA (1 mg/egg) was administered intravenously on embryonic day 13. (f) Representative photographs of CAM vasculature on day 15. (g) Statistical analysis of vascular density performed using ImageJ software (***p < 0.001, n =5). (h) Schematic illustration of the in vivo tumor-targeting study. HCT-116 tumor-bearing mice were intravenously injected with RITC-labeled (SO3⁻)-MSN-PEG/TA (200 mg/kg) and analyzed by <t>multiphoton</t> <t>microscopy.</t> (i) Visualization of the EPR effect. Blood vessels were labeled with FITC–dextran (green), and RITC-labeled (SO3⁻)-MSN-PEG/TA (red) signals were observed 24 hours post-injection. Scale bar = 100 μm. (j) Schematic of the orthotopic colorectal cancer metastasis model. Luciferase-expressing HCT-116 tumor tissue (2 x 10⁶ cells) was implanted into the cecum wall of NOD-SCID mice to establish an orthotopic colorectal cancer model. Mice were intravenously treated with (SO 3 - )-MSN-PEG/TA (equivalent to NPs dose corresponding to 40 mg/kg of IRI@(SO 3 - )-MSN-PEG/TA). (k) Monitoring of orthotopic tumor growth by IVIS imaging from day 3 to day 31. (l) Ex vivo imaging of metastatic lesions: Post-mortem imaging of mice revealed extensive metastasis, with tumor sites identified in organs such as the liver, spleen, kidneys, stomach, and cecum (indicated by cyan arrows).
A1r Mp Multiphoton Advanced Resolution Confocal Microscope, supplied by Nikon, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mpm+200+multiphoton+microscope+body/pmc12304456-240-6-5?v=Nikon
Average 96 stars, based on 1 article reviews
a1r mp multiphoton advanced resolution confocal microscope - by Bioz Stars, 2026-08
96/100 stars
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upright multiphoton microscope  (Bruker Corporation)
96
Bruker Corporation upright multiphoton microscope
Mechanistic evaluation of (SO 3 - )-MSN-PEG/TA on metastasis, focal adhesion turnover, angiogenesis, and tumor targeting. HCT-116 cells were treated with 200 μg/mL of (SO 3 - )-MSN-PEG/TA for 24 hours. (a) Western blot analysis of p-FAK expression levels. (b) Quantitative analysis of p-FAK protein expression relative to the control group (***p < 0.001, n = 3). (c) Immunofluorescence imaging of paxillin (green) and nuclei (blue). Scale bar: 20 μm. (d) Quantitative comparison of the number of FA per cell between control and treated groups (***p < 0.001, n = 5). (e) Schematic representation of the chicken embryo CAM assay. HCT-116 cells were seeded onto the CAM, and (SO 3 - )-MSN-PEG/TA (1 mg/egg) was administered intravenously on embryonic day 13. (f) Representative photographs of CAM vasculature on day 15. (g) Statistical analysis of vascular density performed using ImageJ software (***p < 0.001, n =5). (h) Schematic illustration of the in vivo tumor-targeting study. HCT-116 tumor-bearing mice were intravenously injected with RITC-labeled (SO3⁻)-MSN-PEG/TA (200 mg/kg) and analyzed by <t>multiphoton</t> <t>microscopy.</t> (i) Visualization of the EPR effect. Blood vessels were labeled with FITC–dextran (green), and RITC-labeled (SO3⁻)-MSN-PEG/TA (red) signals were observed 24 hours post-injection. Scale bar = 100 μm. (j) Schematic of the orthotopic colorectal cancer metastasis model. Luciferase-expressing HCT-116 tumor tissue (2 x 10⁶ cells) was implanted into the cecum wall of NOD-SCID mice to establish an orthotopic colorectal cancer model. Mice were intravenously treated with (SO 3 - )-MSN-PEG/TA (equivalent to NPs dose corresponding to 40 mg/kg of IRI@(SO 3 - )-MSN-PEG/TA). (k) Monitoring of orthotopic tumor growth by IVIS imaging from day 3 to day 31. (l) Ex vivo imaging of metastatic lesions: Post-mortem imaging of mice revealed extensive metastasis, with tumor sites identified in organs such as the liver, spleen, kidneys, stomach, and cecum (indicated by cyan arrows).
Upright Multiphoton Microscope, supplied by Bruker Corporation, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mpm+200+multiphoton+microscope+body/pm30562465-41-7-10?v=Bruker+Corporation
Average 96 stars, based on 1 article reviews
upright multiphoton microscope - by Bioz Stars, 2026-08
96/100 stars
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multiphoton confocal microscope  (Nikon)
99
Nikon multiphoton confocal microscope
Mechanistic evaluation of (SO 3 - )-MSN-PEG/TA on metastasis, focal adhesion turnover, angiogenesis, and tumor targeting. HCT-116 cells were treated with 200 μg/mL of (SO 3 - )-MSN-PEG/TA for 24 hours. (a) Western blot analysis of p-FAK expression levels. (b) Quantitative analysis of p-FAK protein expression relative to the control group (***p < 0.001, n = 3). (c) Immunofluorescence imaging of paxillin (green) and nuclei (blue). Scale bar: 20 μm. (d) Quantitative comparison of the number of FA per cell between control and treated groups (***p < 0.001, n = 5). (e) Schematic representation of the chicken embryo CAM assay. HCT-116 cells were seeded onto the CAM, and (SO 3 - )-MSN-PEG/TA (1 mg/egg) was administered intravenously on embryonic day 13. (f) Representative photographs of CAM vasculature on day 15. (g) Statistical analysis of vascular density performed using ImageJ software (***p < 0.001, n =5). (h) Schematic illustration of the in vivo tumor-targeting study. HCT-116 tumor-bearing mice were intravenously injected with RITC-labeled (SO3⁻)-MSN-PEG/TA (200 mg/kg) and analyzed by <t>multiphoton</t> <t>microscopy.</t> (i) Visualization of the EPR effect. Blood vessels were labeled with FITC–dextran (green), and RITC-labeled (SO3⁻)-MSN-PEG/TA (red) signals were observed 24 hours post-injection. Scale bar = 100 μm. (j) Schematic of the orthotopic colorectal cancer metastasis model. Luciferase-expressing HCT-116 tumor tissue (2 x 10⁶ cells) was implanted into the cecum wall of NOD-SCID mice to establish an orthotopic colorectal cancer model. Mice were intravenously treated with (SO 3 - )-MSN-PEG/TA (equivalent to NPs dose corresponding to 40 mg/kg of IRI@(SO 3 - )-MSN-PEG/TA). (k) Monitoring of orthotopic tumor growth by IVIS imaging from day 3 to day 31. (l) Ex vivo imaging of metastatic lesions: Post-mortem imaging of mice revealed extensive metastasis, with tumor sites identified in organs such as the liver, spleen, kidneys, stomach, and cecum (indicated by cyan arrows).
Multiphoton Confocal Microscope, supplied by Nikon, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mpm+200+multiphoton+microscope+body/pmc12106329-180-58-62?v=Nikon
Average 99 stars, based on 1 article reviews
multiphoton confocal microscope - by Bioz Stars, 2026-08
99/100 stars
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mptflex jenlab gmbh, germany  (JenLab GmbH)
90
JenLab GmbH mptflex jenlab gmbh, germany
Mechanistic evaluation of (SO 3 - )-MSN-PEG/TA on metastasis, focal adhesion turnover, angiogenesis, and tumor targeting. HCT-116 cells were treated with 200 μg/mL of (SO 3 - )-MSN-PEG/TA for 24 hours. (a) Western blot analysis of p-FAK expression levels. (b) Quantitative analysis of p-FAK protein expression relative to the control group (***p < 0.001, n = 3). (c) Immunofluorescence imaging of paxillin (green) and nuclei (blue). Scale bar: 20 μm. (d) Quantitative comparison of the number of FA per cell between control and treated groups (***p < 0.001, n = 5). (e) Schematic representation of the chicken embryo CAM assay. HCT-116 cells were seeded onto the CAM, and (SO 3 - )-MSN-PEG/TA (1 mg/egg) was administered intravenously on embryonic day 13. (f) Representative photographs of CAM vasculature on day 15. (g) Statistical analysis of vascular density performed using ImageJ software (***p < 0.001, n =5). (h) Schematic illustration of the in vivo tumor-targeting study. HCT-116 tumor-bearing mice were intravenously injected with RITC-labeled (SO3⁻)-MSN-PEG/TA (200 mg/kg) and analyzed by <t>multiphoton</t> <t>microscopy.</t> (i) Visualization of the EPR effect. Blood vessels were labeled with FITC–dextran (green), and RITC-labeled (SO3⁻)-MSN-PEG/TA (red) signals were observed 24 hours post-injection. Scale bar = 100 μm. (j) Schematic of the orthotopic colorectal cancer metastasis model. Luciferase-expressing HCT-116 tumor tissue (2 x 10⁶ cells) was implanted into the cecum wall of NOD-SCID mice to establish an orthotopic colorectal cancer model. Mice were intravenously treated with (SO 3 - )-MSN-PEG/TA (equivalent to NPs dose corresponding to 40 mg/kg of IRI@(SO 3 - )-MSN-PEG/TA). (k) Monitoring of orthotopic tumor growth by IVIS imaging from day 3 to day 31. (l) Ex vivo imaging of metastatic lesions: Post-mortem imaging of mice revealed extensive metastasis, with tumor sites identified in organs such as the liver, spleen, kidneys, stomach, and cecum (indicated by cyan arrows).
Mptflex Jenlab Gmbh, Germany, supplied by JenLab GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mpm+200+multiphoton+microscope+body/pm30329217-65-9-10?v=JenLab+GmbH
Average 90 stars, based on 1 article reviews
mptflex jenlab gmbh, germany - by Bioz Stars, 2026-08
90/100 stars
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dermainspect  (JenLab GmbH)
90
JenLab GmbH dermainspect
Mechanistic evaluation of (SO 3 - )-MSN-PEG/TA on metastasis, focal adhesion turnover, angiogenesis, and tumor targeting. HCT-116 cells were treated with 200 μg/mL of (SO 3 - )-MSN-PEG/TA for 24 hours. (a) Western blot analysis of p-FAK expression levels. (b) Quantitative analysis of p-FAK protein expression relative to the control group (***p < 0.001, n = 3). (c) Immunofluorescence imaging of paxillin (green) and nuclei (blue). Scale bar: 20 μm. (d) Quantitative comparison of the number of FA per cell between control and treated groups (***p < 0.001, n = 5). (e) Schematic representation of the chicken embryo CAM assay. HCT-116 cells were seeded onto the CAM, and (SO 3 - )-MSN-PEG/TA (1 mg/egg) was administered intravenously on embryonic day 13. (f) Representative photographs of CAM vasculature on day 15. (g) Statistical analysis of vascular density performed using ImageJ software (***p < 0.001, n =5). (h) Schematic illustration of the in vivo tumor-targeting study. HCT-116 tumor-bearing mice were intravenously injected with RITC-labeled (SO3⁻)-MSN-PEG/TA (200 mg/kg) and analyzed by <t>multiphoton</t> <t>microscopy.</t> (i) Visualization of the EPR effect. Blood vessels were labeled with FITC–dextran (green), and RITC-labeled (SO3⁻)-MSN-PEG/TA (red) signals were observed 24 hours post-injection. Scale bar = 100 μm. (j) Schematic of the orthotopic colorectal cancer metastasis model. Luciferase-expressing HCT-116 tumor tissue (2 x 10⁶ cells) was implanted into the cecum wall of NOD-SCID mice to establish an orthotopic colorectal cancer model. Mice were intravenously treated with (SO 3 - )-MSN-PEG/TA (equivalent to NPs dose corresponding to 40 mg/kg of IRI@(SO 3 - )-MSN-PEG/TA). (k) Monitoring of orthotopic tumor growth by IVIS imaging from day 3 to day 31. (l) Ex vivo imaging of metastatic lesions: Post-mortem imaging of mice revealed extensive metastasis, with tumor sites identified in organs such as the liver, spleen, kidneys, stomach, and cecum (indicated by cyan arrows).
Dermainspect, supplied by JenLab GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mpm+200+multiphoton+microscope+body/pm28976087-207-14-17?v=JenLab+GmbH
Average 90 stars, based on 1 article reviews
dermainspect - by Bioz Stars, 2026-08
90/100 stars
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axiovert 200 m channels  (Carl Zeiss)
96
Carl Zeiss axiovert 200 m channels
Mechanistic evaluation of (SO 3 - )-MSN-PEG/TA on metastasis, focal adhesion turnover, angiogenesis, and tumor targeting. HCT-116 cells were treated with 200 μg/mL of (SO 3 - )-MSN-PEG/TA for 24 hours. (a) Western blot analysis of p-FAK expression levels. (b) Quantitative analysis of p-FAK protein expression relative to the control group (***p < 0.001, n = 3). (c) Immunofluorescence imaging of paxillin (green) and nuclei (blue). Scale bar: 20 μm. (d) Quantitative comparison of the number of FA per cell between control and treated groups (***p < 0.001, n = 5). (e) Schematic representation of the chicken embryo CAM assay. HCT-116 cells were seeded onto the CAM, and (SO 3 - )-MSN-PEG/TA (1 mg/egg) was administered intravenously on embryonic day 13. (f) Representative photographs of CAM vasculature on day 15. (g) Statistical analysis of vascular density performed using ImageJ software (***p < 0.001, n =5). (h) Schematic illustration of the in vivo tumor-targeting study. HCT-116 tumor-bearing mice were intravenously injected with RITC-labeled (SO3⁻)-MSN-PEG/TA (200 mg/kg) and analyzed by <t>multiphoton</t> <t>microscopy.</t> (i) Visualization of the EPR effect. Blood vessels were labeled with FITC–dextran (green), and RITC-labeled (SO3⁻)-MSN-PEG/TA (red) signals were observed 24 hours post-injection. Scale bar = 100 μm. (j) Schematic of the orthotopic colorectal cancer metastasis model. Luciferase-expressing HCT-116 tumor tissue (2 x 10⁶ cells) was implanted into the cecum wall of NOD-SCID mice to establish an orthotopic colorectal cancer model. Mice were intravenously treated with (SO 3 - )-MSN-PEG/TA (equivalent to NPs dose corresponding to 40 mg/kg of IRI@(SO 3 - )-MSN-PEG/TA). (k) Monitoring of orthotopic tumor growth by IVIS imaging from day 3 to day 31. (l) Ex vivo imaging of metastatic lesions: Post-mortem imaging of mice revealed extensive metastasis, with tumor sites identified in organs such as the liver, spleen, kidneys, stomach, and cecum (indicated by cyan arrows).
Axiovert 200 M Channels, supplied by Carl Zeiss, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mpm+200+multiphoton+microscope+body/pmc03365982-237-17-16?v=Carl+Zeiss
Average 96 stars, based on 1 article reviews
axiovert 200 m channels - by Bioz Stars, 2026-08
96/100 stars
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mptflex  (JenLab GmbH)
90
JenLab GmbH mptflex
Mechanistic evaluation of (SO 3 - )-MSN-PEG/TA on metastasis, focal adhesion turnover, angiogenesis, and tumor targeting. HCT-116 cells were treated with 200 μg/mL of (SO 3 - )-MSN-PEG/TA for 24 hours. (a) Western blot analysis of p-FAK expression levels. (b) Quantitative analysis of p-FAK protein expression relative to the control group (***p < 0.001, n = 3). (c) Immunofluorescence imaging of paxillin (green) and nuclei (blue). Scale bar: 20 μm. (d) Quantitative comparison of the number of FA per cell between control and treated groups (***p < 0.001, n = 5). (e) Schematic representation of the chicken embryo CAM assay. HCT-116 cells were seeded onto the CAM, and (SO 3 - )-MSN-PEG/TA (1 mg/egg) was administered intravenously on embryonic day 13. (f) Representative photographs of CAM vasculature on day 15. (g) Statistical analysis of vascular density performed using ImageJ software (***p < 0.001, n =5). (h) Schematic illustration of the in vivo tumor-targeting study. HCT-116 tumor-bearing mice were intravenously injected with RITC-labeled (SO3⁻)-MSN-PEG/TA (200 mg/kg) and analyzed by <t>multiphoton</t> <t>microscopy.</t> (i) Visualization of the EPR effect. Blood vessels were labeled with FITC–dextran (green), and RITC-labeled (SO3⁻)-MSN-PEG/TA (red) signals were observed 24 hours post-injection. Scale bar = 100 μm. (j) Schematic of the orthotopic colorectal cancer metastasis model. Luciferase-expressing HCT-116 tumor tissue (2 x 10⁶ cells) was implanted into the cecum wall of NOD-SCID mice to establish an orthotopic colorectal cancer model. Mice were intravenously treated with (SO 3 - )-MSN-PEG/TA (equivalent to NPs dose corresponding to 40 mg/kg of IRI@(SO 3 - )-MSN-PEG/TA). (k) Monitoring of orthotopic tumor growth by IVIS imaging from day 3 to day 31. (l) Ex vivo imaging of metastatic lesions: Post-mortem imaging of mice revealed extensive metastasis, with tumor sites identified in organs such as the liver, spleen, kidneys, stomach, and cecum (indicated by cyan arrows).
Mptflex, supplied by JenLab GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mpm+200+multiphoton+microscope+body/pmc10419023-170-1-4?v=JenLab+GmbH
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Image Search Results


Mechanistic evaluation of (SO 3 - )-MSN-PEG/TA on metastasis, focal adhesion turnover, angiogenesis, and tumor targeting. HCT-116 cells were treated with 200 μg/mL of (SO 3 - )-MSN-PEG/TA for 24 hours. (a) Western blot analysis of p-FAK expression levels. (b) Quantitative analysis of p-FAK protein expression relative to the control group (***p < 0.001, n = 3). (c) Immunofluorescence imaging of paxillin (green) and nuclei (blue). Scale bar: 20 μm. (d) Quantitative comparison of the number of FA per cell between control and treated groups (***p < 0.001, n = 5). (e) Schematic representation of the chicken embryo CAM assay. HCT-116 cells were seeded onto the CAM, and (SO 3 - )-MSN-PEG/TA (1 mg/egg) was administered intravenously on embryonic day 13. (f) Representative photographs of CAM vasculature on day 15. (g) Statistical analysis of vascular density performed using ImageJ software (***p < 0.001, n =5). (h) Schematic illustration of the in vivo tumor-targeting study. HCT-116 tumor-bearing mice were intravenously injected with RITC-labeled (SO3⁻)-MSN-PEG/TA (200 mg/kg) and analyzed by multiphoton microscopy. (i) Visualization of the EPR effect. Blood vessels were labeled with FITC–dextran (green), and RITC-labeled (SO3⁻)-MSN-PEG/TA (red) signals were observed 24 hours post-injection. Scale bar = 100 μm. (j) Schematic of the orthotopic colorectal cancer metastasis model. Luciferase-expressing HCT-116 tumor tissue (2 x 10⁶ cells) was implanted into the cecum wall of NOD-SCID mice to establish an orthotopic colorectal cancer model. Mice were intravenously treated with (SO 3 - )-MSN-PEG/TA (equivalent to NPs dose corresponding to 40 mg/kg of IRI@(SO 3 - )-MSN-PEG/TA). (k) Monitoring of orthotopic tumor growth by IVIS imaging from day 3 to day 31. (l) Ex vivo imaging of metastatic lesions: Post-mortem imaging of mice revealed extensive metastasis, with tumor sites identified in organs such as the liver, spleen, kidneys, stomach, and cecum (indicated by cyan arrows).

Journal: bioRxiv

Article Title: Antimetastatic Sulfonate-Functionalized Mesoporous Silica Nanoparticles Enhance Irinotecan Stability and Delivery for Colorectal Cancer Treatment

doi: 10.1101/2025.11.25.690433

Figure Lengend Snippet: Mechanistic evaluation of (SO 3 - )-MSN-PEG/TA on metastasis, focal adhesion turnover, angiogenesis, and tumor targeting. HCT-116 cells were treated with 200 μg/mL of (SO 3 - )-MSN-PEG/TA for 24 hours. (a) Western blot analysis of p-FAK expression levels. (b) Quantitative analysis of p-FAK protein expression relative to the control group (***p < 0.001, n = 3). (c) Immunofluorescence imaging of paxillin (green) and nuclei (blue). Scale bar: 20 μm. (d) Quantitative comparison of the number of FA per cell between control and treated groups (***p < 0.001, n = 5). (e) Schematic representation of the chicken embryo CAM assay. HCT-116 cells were seeded onto the CAM, and (SO 3 - )-MSN-PEG/TA (1 mg/egg) was administered intravenously on embryonic day 13. (f) Representative photographs of CAM vasculature on day 15. (g) Statistical analysis of vascular density performed using ImageJ software (***p < 0.001, n =5). (h) Schematic illustration of the in vivo tumor-targeting study. HCT-116 tumor-bearing mice were intravenously injected with RITC-labeled (SO3⁻)-MSN-PEG/TA (200 mg/kg) and analyzed by multiphoton microscopy. (i) Visualization of the EPR effect. Blood vessels were labeled with FITC–dextran (green), and RITC-labeled (SO3⁻)-MSN-PEG/TA (red) signals were observed 24 hours post-injection. Scale bar = 100 μm. (j) Schematic of the orthotopic colorectal cancer metastasis model. Luciferase-expressing HCT-116 tumor tissue (2 x 10⁶ cells) was implanted into the cecum wall of NOD-SCID mice to establish an orthotopic colorectal cancer model. Mice were intravenously treated with (SO 3 - )-MSN-PEG/TA (equivalent to NPs dose corresponding to 40 mg/kg of IRI@(SO 3 - )-MSN-PEG/TA). (k) Monitoring of orthotopic tumor growth by IVIS imaging from day 3 to day 31. (l) Ex vivo imaging of metastatic lesions: Post-mortem imaging of mice revealed extensive metastasis, with tumor sites identified in organs such as the liver, spleen, kidneys, stomach, and cecum (indicated by cyan arrows).

Article Snippet: Human colorectal cancer HCT-116 cells (5 × 106) were subcutaneously implanted into the left flank of NOD-SCID mice to establish a heterotopic xenograft model. Mice were intravenously injected with RITC-conjugated (SO 3 −)-MSN-PEG/TA (200 mg/kg), and tumor regions were imaged 24 hours post-injection using multiphoton laser scanning microscopy (LSM; Olympus FVMPE-RS) equipped with a tunable infrared laser (700–1080 nm).

Techniques: Western Blot, Expressing, Control, Immunofluorescence, Imaging, Comparison, Chick Chorioallantoic Membrane Assay, Software, In Vivo, Injection, Labeling, Microscopy, Luciferase, Ex Vivo